Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1933742 | Biochemical and Biophysical Research Communications | 2009 | 5 Pages |
Abstract
Protein–lipid interactions in the nervous system may provide insight into the causes of neurological disorders. In this study, we elucidated if expression of human presenilin 1 (PS1) in a mouse model changes the physico-chemical properties of brain membranes. PS1 is a multifunctional transmembrane protein and part of the γ-secretase complex. This complex is critical for the production of the Alzheimer related amyloid beta peptide. Brain membranes isolated from mice expressing a human wild-type PS1 transgene are less fluid and contain higher cholesterol and sphingomyelin levels. Moreover, our data reveal significant changes in membrane micro-domains and indicate that PS1 induces the formation of lipid rafts.
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Authors
Gunter P. Eckert, Walter E. Müller,