| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1934035 | Biochemical and Biophysical Research Communications | 2009 | 5 Pages |
Abstract
STAT1 mediates Interferon (IFN)-dependent positive and negative regulation of inflammatory gene expression in lung. In this study, we examined the effect of IFN-γ on the expression of SCGB3A1 which is thought to play crucial roles in inflammation and epithelial cell differentiation in lung. We found that expression of SCGB3A1 was down-regulated by IFN-γ in a time- and dose-dependent manner in the murine transformed Clara Cells (mtCC) line. IFN-γ induced the phosphorylation of STAT1, which binds to a STAT-binding element (SBE) in the SCGB3A1 gene promoter, leading to decreased transcriptional activation of this gene.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Atsushi Yamada, Dai Suzuki, Agasa Miyazono, Kumiko Oshima, Akihide Kamiya, Baohong Zhao, Masamichi Takami, Raymond P. Donnelly, Hiroyuki Itabe, Matsuo Yamamoto, Shioko Kimura, Ryutaro Kamijo,