| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1934555 | Biochemical and Biophysical Research Communications | 2009 | 5 Pages |
Abstract
The Epstein–Barr virus (EBV)-encoded latency protein EBNA2 is a nuclear transcriptional activator that is essential for EBV-induced cellular transformation. Here, we show that EBNA2 interacts with STAT3, a signal transducer for an interleukin-6 family cytokine, and enhances the transcriptional activity of STAT3 by influencing its DNA-binding activity. Furthermore, EBNA2 cooperatively acts on STAT3 activation with LMP1. These data demonstrate that EBNA2 acts as a transcriptional coactivator of STAT3.
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Authors
Ryuta Muromoto, Osamu Ikeda, Kanako Okabe, Sumihito Togi, Shinya Kamitani, Masahiro Fujimuro, Shizuko Harada, Kenji Oritani, Tadashi Matsuda,