| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1934658 | Biochemical and Biophysical Research Communications | 2008 | 6 Pages |
Abstract
In this paper were described the purification, the sequencing, and the immunological and biological characterization of a new Kaliotoxin analog, Aam-KTX, from the venom of the scorpion Androctonus amoreuxi. The toxin effects on three cloned Kv channels (Kv1.1, Kv1.2, and Kv1.3) were investigated in Xenopus oocytes using electrophysiology experiments. The Aam-KTX preference for Kv1.3 channel versus Kv1.2 was expected (EC50 values, 1.1 ± 0.02 and 10.4 ± 1.5 nM, respectively) but its total inefficacity on Kv1.1 was very surprising. 3D molecular modeling of Aam-KTX brought putative answers to this difference in selectivity.
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Authors
Najwa Abbas, Maya Belghazi, Yousra Abdel-Mottaleb, Jan Tytgat, Pierre E. Bougis, Marie-France Martin-Eauclaire,