Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1934677 | Biochemical and Biophysical Research Communications | 2008 | 4 Pages |
Abstract
Ischemic preconditioning (IPC) is an evolutionarily conserved endogenous mechanism whereby short periods of non-lethal exposure to hypoxia alleviate damage caused by subsequent ischemia reperfusion (IR). Pharmacologic targeting has suggested that the mitochondrial ATP-sensitive potassium channel (mKATP) is central to IPC signaling, despite its lack of molecular identity. Here, we report that isolated Caenorhabditis elegans mitochondria have a KATP channel with the same physiologic and pharmacologic characteristics as the vertebrate channel. Since C. elegans also exhibit IPC, our observations provide a framework to study the role of mKATP in IR injury in a genetic model organism.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Andrew P. Wojtovich, Lindsay S. Burwell, Teresa A. Sherman, Keith W. Nehrke, Paul S. Brookes,