| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1935124 | Biochemical and Biophysical Research Communications | 2008 | 5 Pages |
Abstract
An efficient and minimally invasive vector system is the “bottle neck” of both gene transfer and drug delivery. Numerous viral and non-viral (synthetic) delivery systems have been developed and improved. Hemagglutinating virus of Japan (HVJ, Sendai virus) envelope vector is a novel and unique system which combined the advantages of viral and non-viral vectors with the following features and advantages: (1) safe and easy as a “non-viral” transfection reagent; (2) delivery of various molecules including plasmid DNA, siRNA, protein, antisense oligonucleotide; (3) wide usability from in vitro to in vivo. In this review, the development, application, and perspectives of the HVJ envelope vector will be discussed.
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Authors
Qingxian Zhang, Ying Li, Yonghong Shi, Yanling Zhang,