Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1935141 | Biochemical and Biophysical Research Communications | 2008 | 6 Pages |
Abstract
In this study, we demonstrated that the two ginger-derived components have a potent and unique pharmacological function in 3T3-L1 adipocytes via different mechanisms. Both pretreatment of 6-shogaol (6S) and 6-gingerol (6G) significantly inhibited the tumor necrosis factor-α (TNF-α) mediated downregulation of the adiponectin expression in 3T3-L1 adipocytes. Our study demonstrate that (1) 6S functions as a PPARγ agonist with its inhibitory mechanism due to the PPARγ transactivation, and (2) 6G is not a PPARγ agonist, but it is an effective inhibitor of TNF-α induced c-Jun-NH2-terminal kinase signaling activation and thus, its inhibitory mechanism is due to this inhibitory effect.
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Authors
Yasuka Isa, Yuri Miyakawa, Masayoshi Yanagisawa, Tsuyoshi Goto, Min-Sook Kang, Teruo Kawada, Yasujiro Morimitsu, Kikue Kubota, Takanori Tsuda,