| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1935185 | Biochemical and Biophysical Research Communications | 2008 | 6 Pages |
Abstract
Reproduction is accurately regulated by metabolic states in mammals. Adiponectin regulates luteinizing hormone (LH) secretion in the pituitary and energy homeostasis in the hypothalamus. We further investigated the gonadotropin-releasing hormone (GnRH) secretion regulation by adiponectin and its related molecular and electrophysiological mechanisms. The results showed that adiponectin receptors (AdipR1 and 2) were expressed in GT1-7 cells derived from hypothalamus neurons. GnRH secretion was inhibited via activation of AMP-activated protein kinase (AMPK). Moreover, we revealed that hyperpolarization of plasma membrane potentials and reduction of calcium influx was also caused by adiponectin.
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Authors
Jun-Ping Wen, Wen-Shan Lv, Jun Yang, Ai-Fang Nie, Xiao-Bing Cheng, Ying Yang, Yan Ge, Xiao-Ying Li, Guang Ning,