| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1935550 | Biochemical and Biophysical Research Communications | 2008 | 5 Pages |
Abstract
In the course of an effort to identify novel agonists of the farnesoid X receptor (FXR), coumestrol was determined to be one such ligand. Reporter and in vitro coactivator interaction assays revealed that coumestrol bound and activated FXR. Treatment of Hep G2 cells with coumestrol stimulated the expression of FXR target genes, thereby regulating the expression of target genes of the liver X receptor and hepatocyte nuclear factor-4α. Through these actions, coumestrol is expected to exert beneficial effects on lipid and glucose metabolism.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Miki Takahashi, Tomohiko Kanayama, Takuya Yashiro, Hidehiko Kondo, Takatoshi Murase, Tadashi Hase, Ichiro Tokimitsu, Jun-ichi Nishikawa, Ryuichiro Sato,