Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1935672 | Biochemical and Biophysical Research Communications | 2008 | 4 Pages |
Abstract
Uromodulin (or Tamm–Horsfall protein) is the most abundant protein in human urine under physiological conditions. Little is known about the molecular mechanism of uromodulin secretion. By extensive Mass Spectrometry analyses we mapped the C-termini of human and murine urinary proteins demonstrating that urinary uromodulin is generated by a conserved C-terminal proteolytic cleavage and retains its entire ZP domain.
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Authors
Sara Santambrogio, Angela Cattaneo, Ilenia Bernascone, Thomas Schwend, Luca Jovine, Angela Bachi, Luca Rampoldi,