Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1935719 | Biochemical and Biophysical Research Communications | 2008 | 4 Pages |
Abstract
Voltage-dependent K+ channels (Kv) are involved in myocyte proliferation and differentiation by triggering changes in membrane potential and regulating cell volume. Since Kv7 channels may participate in these events, the purpose of this study was to investigate whether skeletal muscle Kv7.1 and Kv7.5 were involved during proliferation and myogenesis. Here we report that, while myotube formation did not regulate Kv7 channels, Kv7.5 was up-regulated during cell cycle progression. Although, Kv7.1 mRNA also increased during the G1-phase, pharmacological evidence mainly involves Kv7.5 in myoblast growth. Our results indicate that the cell cycle-dependent expression of Kv7.5 is involved in skeletal muscle cell proliferation.
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Authors
Meritxell Roura-Ferrer, Laura Solé, Ramón Martínez-Mármol, Núria Villalonga, Antonio Felipe,