Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1935773 | Biochemical and Biophysical Research Communications | 2008 | 5 Pages |
Abstract
The immunoglobulin transcription factor-2B (ITF-2B) belongs to the basic helix–loop-helix (bHLH) family of transcription factors. It is ubiquitously expressed and plays a prominent role in the regulation of differentiation processes. Protein sequence alignment of the closely related bHLH transcription factors ITF-2B, HeLa E box protein (HITF4), and the E2A proteins E12 and E47 revealed the presence of a highly conserved protein domain. Functional analysis of this domain demonstrated that it plays an important role in repressing the transcriptional activity of the ITF-2B protein. Moreover, this domain comprises a self-contained transcriptional repressor whose activity depends on specific amino acid residues.
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Authors
A. Herbst, F.T. Kolligs,