| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1935877 | Biochemical and Biophysical Research Communications | 2008 | 5 Pages |
Abstract
We identified human decapping enzyme 2 (hDCP2) as a binding protein with Ro52, being colocalized in processing bodies (p-bodies). We also showed that the N-terminus and C-terminus of Ro52 bound to hDCP2. Moreover, Ro52 enhanced decapping activity of hDCP2 in a dose-dependent manner. Our data support the novel notion of the association between Ro52 with hDCP2 protein in cytoplasmic p-bodies, playing a role in mRNA metabolism in response to cellular stimulation.
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Authors
Tadanori Yamochi, Kei Ohnuma, Osamu Hosono, Hirotoshi Tanaka, Yoshiyuki Kanai, Chikao Morimoto,