Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1936006 | Biochemical and Biophysical Research Communications | 2008 | 5 Pages |
Abstract
In this work, we have examined the possible role of AMP-activated protein kinase (a key energy sensor) in regulating intracellular protein degradation. We have found that AICAR, a known activator of AMPK, has a dual effect. On one hand, it inhibits autophagy by a mechanism independent of AMPK activity; AICAR decreases class III PI3-kinase binding to beclin-1 and this effect counteracts and reverses the known positive effect of AMPK activity on autophagy. On the other hand, AICAR inhibits the proteasomal degradation of proteins by an AMPK-dependent mechanism. This is a novel function of AMPK that allows the regulation of proteasomal activity under conditions of energy demand.
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Authors
Rosa Viana, Carmen Aguado, Inmaculada Esteban, Daniel Moreno, Benoit Viollet, Erwin Knecht, Pascual Sanz,