| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1936079 | Biochemical and Biophysical Research Communications | 2007 | 5 Pages |
Abstract
GATA-2 is a transcription factor expressed in stem and progenitor cells of various cell lineages. In this study, we examined the role of GATA-2 in the differentiation of adipocytes, which are the main components of the microenvironment for hematopoiesis. Suppression of GATA-2 in TBR343, a preadipocytic stromal cell line, resulted in the acceleration of adipocyte differentiation. Conversely, overexpression of GATA-2 induced the resistance of adipocyte differentiation. In addition, regulatory elements of the GATA-2 gene in TBR343 are the same as those in hematopoietic cells. These results suggest that GATA-2 maintains a hematopoietic microenvironment by regulating the differentiation of adipocytes.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Yoko Okitsu, Shinichiro Takahashi, Naoko Minegishi, Junichi Kameoka, Mitsuo Kaku, Masayuki Yamamoto, Takeshi Sasaki, Hideo Harigae,