| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1936212 | Biochemical and Biophysical Research Communications | 2008 | 5 Pages |
Abstract
Apelin, the endogenous ligand of the G protein-coupled APJ receptor has been shown to promote tumor angiogenesis. However, the effect of apelin on inducing angiogenesis in adipose tissue has not been investigated. In this review, we propose a putative role for apelin in promoting angiogenesis in adipose tissue. We further propose that targeting adipose tissue vasculature by blocking apelin signaling with anti-apelin antibodies will lead not only to inhibition of angiogenesis in adipose tissue but also to decreased adiposity.
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Authors
Srujana Rayalam, Mary Anne Della-Fera, Paul A. Krieg, Christopher M. Cox, Allan Robins, Clifton A. Baile,