Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1936390 | Biochemical and Biophysical Research Communications | 2008 | 7 Pages |
Abstract
We recently demonstrated that mitochondrial nitric oxide synthase (mtNOS) functionally couples with mitochondrial respiratory chain complex I to produce nitric oxide [M.S. Parihar, R.R. Nazarewicz, E. Kincaid, U. Bringold, P. Ghafourifar, Association of mitochondrial nitric oxide synthase activity with respiratory chain complex I, Biochem. Biophys. Res. Commun. 366 (2008) 23-28] [1]. The present report shows that inactivation of complex I leads mtNOS to become pro-oxidative. Our findings suggest a crucial role for mtNOS in oxidative stress caused by mitochondrial complex I inactivation.
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Authors
Mordhwaj S. Parihar, Arti Parihar, Frederick A. Villamena, Patrick S. Vaccaro, Pedram Ghafourifar,