Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1936840 | Biochemical and Biophysical Research Communications | 2007 | 6 Pages |
Abstract
Renal hypertrophy, partly due to cell proliferation and hypertrophy, has been found correlated to renal function deterioration in diabetes mellitus. We screened the up-regulated cell cycle related genes to investigate cell growth and the expression of cell cycle regulating proteins at the early stage of diabetic nephropathy using STZ-induced diabetic rats. Cyclin E, CDK2 and P27 were found significantly up-regulated in diabetic kidney. Increased cell proliferation in the kidney was seen at day 3, peaked at day 5, and returned to normal level at day 30. Cyclin E and CDK2 expression also peeked at day 5 and P27 activity peaked at day 14. These findings indicate that a hyperplastic growth period of renal cells is followed by a hypertrophic growth period at the early stage of diabetes. The growth pattern switch may be regulated by cell cycle regulating proteins, Cyclin E, CDK2, and P27.
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Authors
Yanling Zhang, Yonghong Shi, Yaling Liu, Hui Dong, Maodong Liu, Ying Li, Huijun Duan,