Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1936979 | Biochemical and Biophysical Research Communications | 2007 | 6 Pages |
Abstract
Microarray analysis was carried out to identify novel downstream target genes regulated by non-canonical Wnt signaling. We found that Tmod1, known as an actin-capping protein, is up-regulated by Wnt5a, while gelsolin, known as an actin-severing protein, is down-regulated by Wnt5a. As expected from the roles of genes regulated by Wnt5a, L929 cells expressing Wnt5a show abnormal cell shape and a reduced migration rate. Cloning and analysis of the putative promoter show that two conserved sequences, one in the 5â²-end of the first exon and the other in the intron next to the first exon, are necessary for the basal promoter activity.
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Authors
Sangmoon Yun, Yeonmi Rim, Eek-hoon Jho,