Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1937107 | Biochemical and Biophysical Research Communications | 2007 | 5 Pages |
Abstract
In the current study we demonstrate that WT1 is expressed in human lymphocytes. Using the proliferative compound PHA we induced T cell proliferation and growth correlated with an increase in the expression of WT1 measured by RT-PCR, flow cytometry and immunoblot. Co-stimulation with the NO donor SNOG at concentrations of 0, 100, 300 and 600 μM reduced in a concentration dependent way the PHA-induced upregulation of WT1 that correlated with a reduction in T cell proliferation. We conclude that WT1 might be an important component of the NO-dependent regulation of T lymphocyte proliferation and potential function.
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Authors
Marcelo Marcet-Palacios, Francis Davoine, Darryl J. Adamko, Redwan Moqbel, A. Dean Befus,