| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1937187 | Biochemical and Biophysical Research Communications | 2007 | 5 Pages |
Abstract
Glioma is a highly invasive, rapidly spreading form of brain cancer that is resistant to surgical and medical treatment. The recent progresses made in intracellular and ion channels of glioma cells provide a potential new approach for biochemical therapy of brain tumor. In this paper, we reviewed clinical data on chemotherapy by temozolomide and results from new studies on voltage-gated potassium channels, large-conductance Ca2+-activated K+ channels, volume-activated chloride channels, glioma-specific chloride channel and their modulators. These new findings may represent future directions for brain tumor studies and treatment.
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Authors
Li-Tian Yin, Yue-Jun Fu, Qiao-Ling Xu, Jun Yang, Zeng-Li Liu, Ai-Hua Liang, Xiao-Jun Fan, Cheng-Gang Xu,