Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1938539 | Biochemical and Biophysical Research Communications | 2007 | 6 Pages |
Abstract
MYO18B is a class XVIII myosin, cloned as a tumor suppressor gene candidate. To investigate the mechanisms of MYO18B-dependent tumor suppression, MYO18B-interacting proteins were searched for by a yeast two-hybrid screen. HOMER2, a Homer/Ves1 family protein, was identified as a binding partner of MYO18B. These proteins co-localized in the regions of membrane protrusion and stress fiber, which are known as ones with filamentous actin-rich structures. Expression of HOMER2 enhanced the ability of MYO18B to suppress anchorage-independent growth. These results indicate that HOMER2 and MYO18B cooperate together in tumor suppression.
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Authors
Rieko Ajima, Keiko Kajiya, Takeshi Inoue, Masachika Tani, Yoko Shiraishi-Yamaguchi, Masahiro Maeda, Tatsuya Segawa, Teiichi Furuichi, Kazuo Sutoh, Jun Yokota,