Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1938616 | Biochemical and Biophysical Research Communications | 2007 | 5 Pages |
Abstract
Multidrug transporters are of considerable importance because they present problems in the treatment of infectious disease and cancer. A central issue is the ability of efflux pumps to recognize an astounding array of structurally diverse compounds. The yeast Pdr5p efflux pump, which is a member of the ATP-binding cassette superfamily, has at least 3 substrate-binding sites, each of which appears to use different chemical properties to transport compounds. All Pdr5p substrates, however, have a size requirement that is independent of hydrophobicity.
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Biochemistry
Authors
John Golin, Suresh V. Ambudkar, Leopold May,