Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1938843 | Biochemical and Biophysical Research Communications | 2006 | 5 Pages |
Abstract
Triggered self-activation of factor XII, a blood coagulation protease, was utilized for the amplified visual detection of ss-DNA targets in a non-sequence specific way. Factor XII holds potential as a low-affinity and therefore non-interfering probe for DNA secondary structure and for the screening of protein binding to ss-DNA. The observation that ss-DNA also accelerates coagulation of human blood plasma is relevant to the emerging field of aptamer therapeutics.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Valeri Pavlov, Michael Zorn, Roland Krämer,