Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1938891 | Biochemical and Biophysical Research Communications | 2007 | 5 Pages |
Abstract
The persistence of highly pathogenic avian influenza within wild bird populations has forged interest in control measures to limit a possible human pandemic. We therefore investigated the efficacy of low dose oral administration of IFN-α as a potential therapy against influenza infection in a murine model. We have identified an optimal low oral dose of IFN-α that when delivered daily as prophylactic therapy protects C57BL/6J mice from a lethal challenge with mouse adapted human influenza virus A/PR/8/34 (H1N1). These results provide strong support for the application of low dose type 1 IFN pretreatment to human influenza control.
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Authors
Manfred W. Beilharz, Joseph M. Cummins, Alayne L. Bennett,