Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1940270 | Biochemical and Biophysical Research Communications | 2006 | 7 Pages |
Abstract
Radiation therapy is a widely used cancer treatment, but it is unable to completely block cancer metastasis. The lymphatic vasculature serves as the primary route for metastatic spread, but little is known about how lymphatic endothelial cells respond to radiation. Here, we show that lymphatic endothelial cells in the small intestine and peri-tumor areas are highly resistant to radiation injury, while blood vessel endothelial cells in the small intestine are relatively sensitive. Our results suggest the need for alternative therapeutic modalities that can block lymphatic endothelial cell survival, and thus disrupt the integrity of lymphatic vessels in peri-tumor areas.
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Authors
Hoon Ki Sung, Tohru Morisada, Chung-Hyun Cho, Yuichi Oike, Jayhun Lee, Eon Ki Sung, Jae Hoon Chung, Toshio Suda, Gou Young Koh,