Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1940489 | Biochemical and Biophysical Research Communications | 2006 | 8 Pages |
The final common pathway in the demise of dopaminergic neurons in Parkinson’s disease may involve oxidative stress and excitotoxicity. In this study, we examined the neuroprotective effects of a novel ATP-sensitive potassium channel (KATP) opener, iptakalim (IPT), against H2O2-induced cytotoxicity in rat dopaminergic PC12 cells. Pretreatment with IPT could attenuate increased extracellular glutamate levels and inhibit calcium influxing induced by H2O2. Moreover, IPT regulated the expressions of bcl-2 and bax which were responsible for inhibiting apoptosis in PC12 cells. These protective effects of IPT were abolished by selective mitoKATP channel blocker 5-hydroxydecanoate. Therefore, IPT can protect PC12 cells against H2O2-induced oxidative injury via activating mitoKATP channel.