Article ID Journal Published Year Pages File Type
1940685 Biochemical and Biophysical Research Communications 2006 5 Pages PDF
Abstract

Gene rearrangements in a head-to-tail fashion have been described several times for gene segments of the rota-, phytoreo-, and orbiviruses. Several mechanisms have been proposed to explain the occurrence of partial duplications, however, none of these models has been fully satisfactory to explain the occurrence of all the observed duplicated genes. Based on recently available structural data about the λ3 RNA-dependent-RNA-polymerase of reoviruses, we propose the ‘loop model’ as a plausible explanation for the occurrence of partial gene duplications in dsRNA viruses.

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