Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1940776 | Biochemical and Biophysical Research Communications | 2006 | 9 Pages |
Abstract
We previously reported that deletion of the Fgf2 gene (Fgf2−/−) resulted in decreased bone mass in adult mice. This study examines the effect of haplo-insuffiency (Fgf2+/−) on bone loss in vertebrae from these mutant mice. Fgf2+/+ mice attained peak bone mass at 8–9 months of age. In contrast BMD was significantly reduced in vertebrae from adult (8–9) Fgf2+/− mice. Exogenous FGF-2 rescued reduced bone nodule formation in Fgf2+/− and Fgf2−/− cultures. Runx2 mRNA was reduced in cultures from Fgf2+/− and Fgf2−/− mice. FGF receptor2 mRNA and protein were markedly reduced in Fgf2+/− and Fgf2−/− mice. Decreased bone formation in Fgf2 mutant mice may correlate with impaired FGFR signaling, decreased Runx2 gene expression.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
T. Naganawa, L. Xiao, E. Abogunde, T. Sobue, I. Kalajzic, M. Sabbieti, D. Agas, M.M. Hurley,