Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1941135 | Biochemical and Biophysical Research Communications | 2006 | 7 Pages |
Abstract
Collapsin response mediator protein-2 or Crmp-2 plays a critical role in the establishment of neuronal polarity. In this study, we present evidence that apart from its functions in neurodevelopment, Crmp-2 is also involved in pathways that regulate the proliferation of non-neuronal cells through its phosphorylation by regulatory proteins. We show that Crmp-2 undergoes dynamic phosphorylation changes in response to contact inhibition-induced quiescence and that hyperphosphorylation of Crmp-2 occurs in a tumor. We further suggest that de-regulation of Crmp-2 phosphorylation levels at certain amino acid residues may lead to aberrant cell proliferation and consequently, tumorigenesis.
Keywords
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Authors
Candice Ginn T. Tahimic, Nozomi Tomimatsu, Ryuichi Nishigaki, Akiko Fukuhara, Tosifusa Toda, Kozo Kaibuchi, Goshi Shiota, Mitsuo Oshimura, Akihiro Kurimasa,