Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1941645 | Biochemistry and Biophysics Reports | 2016 | 5 Pages |
Abstract
This study demonstrates the role of TLR4 in cobalt-mediated immune cell chemotaxis and provides a potential mechanism by which cobalt ions may contribute to the immune cell infiltrate surrounding failed metal hip replacements. It also highlights the TLR4 signalling pathway as a potential therapeutic target in preventing cobalt-mediated inflammation.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Helen Lawrence, David J. Deehan, James P. Holland, Sami A. Anjum, Amy E. Mawdesley, John A. Kirby, Alison J. Tyson-Capper,