| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1944072 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2015 | 9 Pages |
•Voltage-gated sodium channels (VGSC) enhance cancer cell motility and invasiveness.•A lot is known on how the activity, expression, degradation of VGSC are regulated.•How VGSC enhance motility and invasiveness is poorly described and understood.•Several proteins which are regulated by VGSC activity are known.•Links are missing between VGSC, Na+ and these proteins.
Voltage-gated sodium channels are abnormally expressed in tumors, often as neonatal isoforms, while they are not expressed, or only at a low level, in the matching normal tissue. The level of their expression and their activity is related to the aggressiveness of the disease and to the formation of metastases. A vast knowledge on the regulation of their expression and functioning has been accumulated in normal excitable cells. This helped understand their regulation in cancer cells. However, how voltage-gated sodium channels impose a pro-metastatic behavior to cancer cells is much less documented. This aspect will be addressed in the review. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers.
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