Viral channel proteins in intracellular protein–protein communication: Vpu of HIV-1, E5 of HPV16 and p7 of HCV

•Known and predicted interactions of viral channel proteins with host proteins•Interactions of the TMDs of viral proteins with host proteins•Vpu of HIV1, E5 of HPV and p7 of HCV

Viral channel forming proteins are known for their capability to make the lipid membrane of the host cell and its subcellular compartments permeable to ions and small compounds. There is increasing evidence that some of the representatives of this class of proteins are also strongly interacting with host proteins and the effectiveness of this interaction seems to be high. Interaction of viral channel proteins with host factors has been proposed by bioinformatics approaches and has also been identified experimentally. An overview of the interactions with host proteins is given for Vpu from HIV-1, E5 from HPV-16 and p7 from HCV. This article is part of a Special Issue entitled: Viral Membrane Proteins — Channels for Cellular Networking.

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