Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1944375 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2013 | 7 Pages |
Abstract
⺠Anesthetics halothane and ketamine bound to multiple sites of the α4β2 nAChR. ⺠A common intra-subunit anesthetic site was near the extracellular end of the β2 TM. ⺠Halothane occupied inter-subunit sites near the extracellular end of the TM domain. ⺠Both drugs bound to intra- and inter-subunit sites near the selectivity filter. ⺠Anesthetics induced, directly or allosterically, dynamics changes of α4β2.
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Authors
Vasyl Bondarenko, David Mowrey, Lu Tian Liu, Yan Xu, Pei Tang,