Structure and dynamics of the two amphipathic arginine-rich peptides RW9 and RL9 in a lipid environment investigated by solid-state NMR and MD simulations

► RW9 and RL9 are located in the lipid/water interface. ► Both peptides have small influence on membrane slightly increasing its flexibility. ► Both peptides enrich POPG almost 2fold in an area of 12 Å around them. ► Both peptides reverse their orientation during binding to the membrane. ► Structural changes were observed during peptide reorientation.