| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1944490 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 9 Pages |
Abstract
⺠We simulated OmpLA in DLPC to elucidate molecular events in response to charged residues in the bilayer. ⺠An Arg mutation on the lipid surface of OmpLA induces water dimples that maintain the hydration of the guanidinium group. ⺠A Leu mutation on the lipid surface of OmpLA is in a dehydrated environment. ⺠We validate OmpLA in DLPC membranes as a molecular system for experimental hydrophobicity scales.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Patrick J. Fleming, J. Alfredo Freites, C. Preston Moon, Douglas J. Tobias, Karen G. Fleming,