| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1944508 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 8 Pages |
Abstract
⺠Two homology models of the Hv1 proton channel are presented. ⺠The models are based on two alignments with the voltage-sensing domain of a potassium channel of known structure. ⺠Both models support water wires, but the wire is more stable in one of the models. ⺠No water flux is observed in the model with the most robust water wire. ⺠The model with the most robust wire is supported by experimental studies and modeling of a mutant.
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Authors
Mona L. Wood, Eric V. Schow, J. Alfredo Freites, Stephen H. White, Francesco Tombola, Douglas J. Tobias,