| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1944522 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 9 Pages |
Abstract
âºThe zebrafish genome harbors a family K2P potassium channels. âºK2P10.1 (TREK2) was cloned from zebrafish cDNA. âºHuman and zebrafish K2P10.1 exhibit similar ion selectivity and modulation. âºhK2P10.1 and zK2P10.1 are targeted by common antiarrhythmic drugs. âºZebrafish may serve as a model to study the role of K2P in physiology and disease
Keywords
M1 and M2PKCphorbol 12-myristate 13-acetateK2P channelRMPISHTWIK-related K+ channelORFTWIKIKPTREKTRAAKIn situ hybridizationPMAArachidonic acidAmino acidsPUFAElectrophysiologyHumancoding sequencecurrenttransmembrane domainopen reading frameUTR یا untranslated regions untranslated regionRatTaskvoltagePalmitic acidMembrane potentialresting membrane potentialreversal potentialProtein kinase CCdSIon channelZebrafishErev
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Authors
Jakob Gierten, David Hassel, Patrick A. Schweizer, Rüdiger Becker, Hugo A. Katus, Dierk Thomas,