| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1944528 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 8 Pages |
Abstract
⺠We investigated the interaction between recombinant PAC and Langmuir monolayers. ⺠Three catalytically active, truncated PACs with increasing deletion of the C-terminal region were studied. ⺠The affinity to DPPG decreased with increased deletion of the C-terminal region. ⺠Using PM-IRRAS we confirm the importance of the C-terminal region for PAC-membrane interaction. ⺠We consider this interaction fundamental for the protein to reach the cytosol and develop its toxic activity.
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Authors
Luis Fernando Reyes, Thatyane M. Nobre, Felippe J. Pavinatto, Maria E.D. Zaniquelli, Luciano Caseli, Osvaldo N. Jr., Ana Paula U. Araújo,