Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1945054 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2009 | 20 Pages |
Abstract
In this review we describe the state-of-the-art of computer simulation studies of lipid membranes. We focus on collective lipid-lipid and lipid-protein interactions that trigger deformations of the natural lamellar membrane state, showing that many important biological processes including self-aggregation of membrane components into domains, the formation of non-lamellar phases, and membrane poration and curving, are now amenable to detailed simulation studies.
Keywords
GMOphosphatic acidDipalmitoyl-PCDioleoyl-PCdimyristoyl-PCLipid flip-flopDOPCDPDPoPCVesicleDAPCAFMdMPCSSMDPPCPMFAMPDMSOBARPhase transformationSelf-assemblyCoarse grainedDissipative particle dynamicsMolecular dynamicsDimethylsulfoxideMonte CarloBiological membranephosphatidylethanolaminePhosphatidylserineComputer modelingNon-Lamellar phasemembrane poreAtomic Force MicroscopePotential of mean forceAntimicrobial peptide
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Authors
Siewert J. Marrink, Alex H. de Vries, D. Peter Tieleman,