Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1945208 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2009 | 7 Pages |
Abstract
Rap proteins are Ras-like small GTP-binding proteins that amongst others are involved in the control of cell–cell and cell–matrix adhesion. Several Rap guanine nucleotide exchange factors (RapGEFs) function to activate Rap. These multi-domain proteins, which include C3G, Epacs, PDZ-GEFs, RapGRPs and DOCK4, are regulated by various different stimuli and may function at different levels in junction formation. Downstream of Rap, a number of effector proteins have been implicated in junctional control, most notably the adaptor proteins AF6 and KRIT/CCM1. In this review, we will highlight the latest findings on the Rap signaling network in the control of epithelial and endothelial cell–cell junctions.
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Authors
Willem-Jan Pannekoek, Matthijs R.H. Kooistra, Fried J.T. Zwartkruis, Johannes L. Bos,