Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1945781 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2007 | 13 Pages |
Abstract
G protein-coupled receptors (GPCRs) are widely implicated in human heart disease, making them an important target for cardiac drug therapy. The most commonly studied and clinically targeted cardiac GPCRs include the adrenergic, angiotensin, endothelin, and adenosine receptors. Treatment options focusing on the complex and integrated signaling pathways of these GPCRs are critical for the understanding and amelioration of heart disease. The focus of this review is to highlight the most commonly studied and clinically targeted cardiac GPCRs, placing emphasis on their common signaling components implicated in cardiac disease.
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Authors
Natasha C. Salazar, Juhsien Chen, Howard A. Rockman,