Article ID Journal Published Year Pages File Type
1946463 Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2013 5 Pages PDF
Abstract

•Cdk8 is a cyclin-dependent kinase and a evolutionary conserved component of the Mediator complex.•Cdk8 influences multiple steps in cell cycle progression.•Cdk8 governs the stability of gene specific transcription factors via the ubiquitin-dependent proteolysis pathway.

Cyclin dependent kinase 8 (Cdk8) is a component of Mediator, an evolutionary conserved multiprotein complex that regulates RNA polymerase II-dependent transcription. Cdk8 has been implicated as a regulator of multiple steps in cell cycle progression. We here discuss recent advances in our understanding of Cdk8 function and a possible role for Mediator as a hub for integrating transcription regulation with cell cycle progression.

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