Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1946498 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2013 | 7 Pages |
Pioneering studies on eukaryotic transcription were undertaken with the bacterial system in mind. Will the bacterial paradigm apply to eukaryotes? Are there promoter sites scattered in the eukaryotic genome, and sigma-like proteins? Why three forms of RNA polymerase in eukaryotic cells? Why are they structurally so complex, in particular RNA polymerases I and III, compared to the bacterial enzyme? These questions and others that were raised along the way are evoked in this short historical survey of odd RNA polymerases studies, with some emphasis on the contribution of these studies to our global understanding of eukaryotic transcription systems. This article is part of a Special Issue entitled: Transcription by Odd Pols.
► Eukaryotic transcription studies: a Russian dolls story ► Old, unanswered questions ► Uncompleted quest for factors and regulators