Article ID Journal Published Year Pages File Type
1946563 Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2012 12 Pages PDF
Abstract

The regulation of gene expression is the most basic level at which genotypes encoded in DNA can manifest themselves into observable phenotypes. In eukaryotes, gene regulatory networks (GRNs) describe the regulatory web through which transcription factors and microRNAs tightly regulate the spatial and temporal expression of genes. In yeast, Escherichia coli, and animals the study of GRNs has uncovered many of the network properties responsible for creating complex regulatory behavior such as organism growth, development, and response to environmental stimuli. In plants, the study of GRNs is just starting to gain momentum thanks to new high quality genomes and the development of new tools for GRN mapping. Here, we review the latest advancements in the study of plant GRNs and describe the tools and techniques used to produce them. We also discuss the emerging field of network dynamics and the methods currently being developed to measure network dynamics and function in plants.

►The study of plant GRNs is lagging behind that of animal and unicellular model systems but is quickly gaining momentum. ►The functional definition of a promoter is evolving from positional to dynamic. ►We discuss techniques for GRN mapping, comparing TF-centered and gene-centered approaches.

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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