Article ID Journal Published Year Pages File Type
1946591 Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2012 9 Pages PDF
Abstract

DNA double-strand breaks (DSBs) occur in the context of a highly organized chromatin environment and are, thus, a significant threat to the epigenomic integrity of eukaryotic cells. Changes in break-proximal chromatin structure are thought to be a prerequisite for efficient DNA repair and may help protect the structural integrity of the nucleus. Unlike most bona fide DNA repair factors, chromatin influences the repair process at several levels: the existing chromatin context at the site of damage directly affects the access and kinetics of the repair machinery; DSB induced chromatin modifications influence the choice of repair factors, thereby modulating repair outcome; lastly, DNA damage can have a significant impact on chromatin beyond the site of damage. We will discuss recent findings that highlight both the complexity and importance of dynamic and tightly orchestrated chromatin reorganization to ensure efficient DSB repair and nuclear integrity. This article is part of a Special Issue entitled: Chromatin in time and space.

► Chromatin reorganization is a key aspect of eukaryotic DNA repair. ► DNA break-induced chromatin remodeling affects repair factor access and choice. ► The pre-existing chromatin environment influences DNA repair kinetics and outcome. ► DNA breaks cause epigenomic changes that extend beyond the site of damage.

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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