Article ID Journal Published Year Pages File Type
1946660 Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2011 9 Pages PDF
Abstract

The finely regulated series of events that span from the birth of a cell to the production of two new born cells encompass the cell cycle. Cell cycle progression occurs in a unidirectional manner and requires passing through a number of stages in response to cellular, developmental and environmental cues. In addition to these signaling cascades, transcriptional regulation plays a major role and acts coordinately with genome duplication during S-phase and chromosome segregation during mitosis. In this context, chromatin is revealing as a highly dynamic and major player in cell cycle regulation not only owing to the changes that occur as a consequence of cell cycle progression but also because some specific chromatin modifications are crucial to move across the cell cycle. These are particularly relevant for controlling transcriptional activation and repression as well as initiation of DNA replication and chromosome compaction. As a consequence the epigenetic landscape of a proliferating cell is very complex throughout the cell cycle. These aspects of chromatin dynamics together with the impact of epigenetic modifications on cell proliferation will be discussed in this article. This article is part of a Special Issue entitled: Epigenetic Control of cellular and developmental processes in plants.

Research highlights► Chromatin is revealing as highly dynamic during cell cycle progression. ► Specific chromatin modifications are crucial to move across the cell cycle. ► These refer to transcriptional control, genome duplication and chromsome compaction. ► The epigenetic landscape of a proliferating cell is very complex.

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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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