Article ID Journal Published Year Pages File Type
1946686 Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2011 10 Pages PDF
Abstract

The mechanisms by which nuclear hormone receptors (NHRs) regulate transcription are highly dynamic and require interplay between a myriad of regulatory protein complexes including the 26S proteasome. Protein degradation is the most well-established role of the proteasome; however, an increasing body of evidence suggests that the 26S proteasome may regulate transcription in proteolytic and nonproteolytic mechanisms. Here we review how these mechanisms may apply to NHR-mediated transcriptional regulation. This article is part of a Special Issue entitled The 26S Proteasome: When degradation is just not enough!

Research highlights► Nuclear hormone receptors are specialized transcriptional regulators that interact directly with chromatin. ► The proteasome regulates NHR-mediated transcription via proteolytic and non-proteolytic mechanisms. ► The proteasome expands NHR transcriptional networks by modulating chromatin plasticity.

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