Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1946835 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2010 | 6 Pages |
Abstract
The majority of human genes undergo alternative splicing, which is frequently altered in response to physiological stimuli. DARPP-32 (dopamine and cAMP regulated phosphoprotein, 32 kDa) is a component of PKA-dependent signaling pathways. Here we show that DARPP-32 binds directly to the splicing factor tra2-beta1 (transformer 2). DARPP-32 changes the usage of tra2-beta1 dependent alternative exons in a concentration-dependent manner, suggesting that the DARPP-32:tra2-beta1 interaction is a molecular link between signaling pathways and pre-mRNA processing.
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Authors
Natalya Benderska, Kristina Becker, Jean-Antoine Girault, Cord-Michael Becker, Athena Andreadis, Stefan Stamm,