Nicotine enhances the malignant potential of human pancreatic cancer cells via activation of atypical protein kinase C

Article ID	Journal	Published Year	Pages	File Type
1947304	Biochimica et Biophysica Acta (BBA) - General Subjects	2016	12 Pages	PDF

Abstract

Nicotine induces aberrant activation of aPKC via nAChR/PI3K signaling in PC cells, resulting in enhancement of cellular proliferation, migration and invasion.

Keywords

PI3K MCA nAChR LY294002 aPKC lethal (2) giant larvae Par6 Immunoprecipitation EMT Pancreatic cancer Phosphatidylinositol 3-kinase cigarette smoking Nicotine atypical protein kinase C Epithelial-mesenchymal transition Nicotine acetylcholine receptor

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Nicotine enhances the malignant potential of human pancreatic cancer cells via activation of atypical protein kinase C

Authors

Takehiko Hanaki, Yosuke Horikoshi, Kazuhiro Nakaso, Masato Nakasone, Yoshinori Kitagawa, Masataka Amisaki, Yosuke Arai, Naruo Tokuyasu, Teruhisa Sakamoto, Soichiro Honjo, Hiroaki Saito, Masahide Ikeguchi, Kazunari Yamashita, Shigeo Ohno, Tatsuya Matsura,